A 1. Oily drugs and low melting point drugs are most suitable for making soft capsules. Oily drugs and drugs that are liquid or semi-solid at room temperature used to be treated by adsorption, solidification and other technologies during preparation for preparation. As the addition of auxiliary materials such as adsorbent increases the volume, or heating and drying treatment is required during preparation, the drugs are easy to dissociate or exude from auxiliary materials such as adsorbent, causing loss of the main drug and affecting the efficacy. However, soft capsule is used to dissolve oily drugs and low melting drugs with a purpose soluble solvent or make emulsion for filling or dropping pills, which eliminates the need for adsorption auxiliary materials. It not only miniaturizes the preparation, but also avoids problems such as drug dissociation and seepage. Such as vitex oil capsules and indomethacin farnesyl ester capsules.
2. Drugs that are sensitive to light, unstable in case of damp and heat, and easy to oxidize can be made into soft capsules. Some drugs, such as volatile oil, are sensitive to light; Some drugs are easy to decompose and volatilize in case of damp and heat; Some drugs are easily oxidized during preparation and storage. In order to prevent the drug from decomposing in the presence of light, light shielding materials such as titanium dioxide or iron oxide can be added to the capsule material to obtain good light stability. In order to prevent the drug from contacting with air, inert gas can be introduced during the preparation process. The capsule material of soft capsule is composed of glycerin and gelatin, with thick wall and no permeability, so soft capsule is an excellent preparation to prevent drug oxidation. For example, vitamin E capsule, active vitamin D3 capsule.
3. Soft capsules can be made into rectal suppository. The method is to dissolve or make the main drug into oil soluble suspension to prepare soft capsules, and then make the capsules into suppositories. Compared with general suppository, rectal capsule suppository is easier to diffuse and absorb in rectum, and its preparation method is simpler and easier to use. At present, the varieties listed abroad include rectal capsules such as betamethasone and indomethacin.
4. Drugs with bad smell and micro active drug soft capsules can cover up the bad smell of drugs. The dosage of some micro active drugs is very small, so it is best to make soft capsules.
5. The drug soft capsules with volatile components and easy to escape can not only ensure the loss of volatile components in medicinal materials, but also avoid the escape of volatile oil after the preparation is placed, improving the quality and efficacy of drugs.
6. Hydrophobic drugs with poor bioavailability can be greatly improved by making them into microemulsions with oily carriers and putting them into soft capsules. If other solid preparations are used, it is difficult for such drugs to reach the effective blood concentration.
